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A shorter Breakdown of Dosing and AdministrationBy rateship27
The saturation dose for most studies around the GHRPs (GHRP-6, GHRP-2, Ipamorelin & Hexarelin) is described as either 100mcg or 1mcg/kg.
What meaning is that 100mcg will saturate the receptors fully, but if you add another 100mcg to that dose only 50% of this portion will likely be effective. In the event you add one more 100mcg fot it dose only about 25% is going to be effective. The final 100mcg might add a little something to GH release but that's it.
So 100mcg will be the saturation dose as well as add more around 300 to 400mcg and acquire a little more effect.
A 500mcg dose will never be far better then a 400mcg, perhaps even if it's just more effective then 300mcg.
Any additional issues are desensitization & cortisol/prolactin side-effects.
xpeptides.com is around as efficacious as GHRP-6 in causing GH release but even at higher dose (above 100mcg) it does not create prolactin or cortisol.
GHRP-6 at the saturation dose 100mcg doesn't really increase prolactin & cortisol but may achieve this slightly at higher doses. This rise remains to be within the normal range.
GHRP-2 might be a more efficacious then GHRP-6 at causing GH release but on the saturation dose or more may make a slight to moderate surge in prolactin & cortisol. This rise continues to be inside normal range although doses of 200 - 400mcg will make it the top end of the normal range.
Hexarelin is among the most efficacious out of all the GHRPs at causing a boost in GH release. However it gets the highest possible ways to could also increase cortisol & prolactin. This rise will occur even on the 100mcg saturation dose. This rise will get to the higher amounts of what's understood to be normal.
GHRP-6 can be utilized at saturation dose (100mcg) 3 to 4 times a day without risk of desensitization.
GHRP-2 probably at saturation dose more than once a day will not lead to desensitization.
Hexarelin can produce desensitization however in a long-term read the pituitary recovered its sensitivity so that there were not long-term loss in sensitivity at saturation dose. However dosing Hexarelin even at 100mcg 3 times each day will more than likely result in some down regulation within Fourteen days.
If desensitization would ever occur for almost any of these GHRPs simply stopping use stay will remedy this effect.
Chronic using GHRP-6 at 100mcg dosed more than once per day each day will not likely cause pituitary problems, nor significant prolactin or cortisol problems, nor desensitize.
Now Sermorelin, GHRH (1-44) and GRF(1-29) each one is basically GHRH where you can short half-life in plasma due to quick cleavage relating to the 2nd & 3rd amino acid. That is no worry naturally as this hormone is secreted in the hypothalamus and travels a short distance for the underlying anterior pituitary and is not really be subject to enzymatic cleavage. The production from your hypothalamus and binding to somatotrophs (pituitary cells) happens quickly.
But once injected in the body it requires to circulate before finding its method to the pituitary therefore within 3 minutes it really is already being degraded.
This is why GHRH from the above forms should be dosed high to obtain an impression.
All GHRH analogs swap Alanine with the 2nd position for D-Alanine helping to make the peptide resistance against quick cleavage at that position. This means analogs is often more effective when injected at smaller dosing.
The analog tetra or 4 substituted GRF(1-29) sometimes called CJC w/o the DAC or described by me as modified GRF(1-29) has other protein modifications. They may be a glutamine (Gln or Q) in the 8-position, alanine (Ala or even a) in the 15-position, along with a leucine (Leu or L) on the 27-position.
The alanine with the 8th position enhances bioavailability however the other two amino substitutions are created to improve the manufacturing process (i.e. create manufacturing stability).
To be used in vivo, in humans, the GHRH analog called CJC w/o the DAC or tetra (4) substituted GRF(1-29) or modified GRF(1-29) is an extremely effective peptide which has a half-life probably 30+ minutes.
That's long enough to get completely effective.
The saturation dose can be understood to be 100mcg.
Problem w/ Using any GHRH alone
The challenge with employing a GHRH the stronger analogs is because they are simply successful when somatostatin is low (the GH inhibiting hormone). When you unluckily administer inside a trough (or whenever a GH pulse is just not organic) you will add little or no GH release. If however you luckily administer after a rising wave or GH pulse (somatostatin will not be active at this stage) you are going to enhance GH release.
Solution is GHRP + GHRH analog
The perfect solution is is straightforward and noteworthy. You administer a GHRH analog using a GHRP. The GHRP creates a pulse of GH. It lets you do this through several mechanisms. One mechanism is the reduction of somatostatin release from the hypothalamus, these guys a deduction of somatostatin influence on the pituitary, still another is increased release of GHRH in the brain last but not least GHRPs act on a single pituitary cells (somatotrophs) similar to GHRHs but use a different mechanism to raise cAMP formation that may further cause GH release from somatotroph stores.
GHRH also offers a means of reciprocally reinforcing GHRPs action.
It makes sense a synergistic GH release.
The GH is just not additive it can be synergistic. What i mean is:
If GHRH on its own will result in a GH release worth 2
and GHRP itself may cause a GH release worth 5
Together the GH is not 7 (5+2) it happens to state 16!
A solid protocol
A great protocol should be to work with a GHRP + a GHRH analog pre-bed (to guide the nightime pulse) and once or twice each day.
For anti-aging, deep restful restorative sleep, the once during the night dosing is all you may need. With an adult aged 40+ it is enough to regenerate GH to youthful levels.
Nevertheless for bodybuilding or fatloss or injury repair multiple dosings can be effective.
The GHRH analog can be used at 100mcg in addition to being high as you desire without difficulty.
The GHRP-6 can invariably be utilized at 100mcg w/o problems but a dose of 200mcg will likely be fine also.
Again desensitization is one area to help keep a record of particularly with all the highest doses of GHRP-2 and many types of doses of Hexarelin.
So 100 - 200mcg of GHRP-6 + 100 - 500mcg+ of a GHRH analog taken together will likely be effective.
This is dosed repeatedly a day to be impressive.
An excellent approach might be more conservative at 100mcg of GHRP-6 + 100mcg of the GHRH analog dosed either once, twice, 3 or 4 times per day.
When dosing several times every day a minimum of 3 hours should separate the administrations.
The real difference is every day dosing pre-bed gives a youthful restorative level of GH while multiple dosing and even higher levels can give higher GH & IGF-1 levels when in conjunction with diet & exercise will cause muscle gain & fatloss.
Dose w/o food
Administration should ideally be achieved on either jail stomach or with only protein in the stomach. Fats & carbs blunt GH release. So administer the peptides and wait about 20 minutes (no more then 30 but truth be told then A quarter-hour) to nibble on. At that time the GH pulse has about hit the height and you will eat what you want.
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